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doi: 10.1016/j.ctcp.2016.11.008 149 ChenJGuoQY-HPRenQ-LChiLHuR-Ket al

Figure 2 It has been hypothesized by certain researchers that there is an interaction between retinal macrophages and ferroptosis, given the resemblance in the functions of the macrophages and the traits of ferroptosis ( Macrophages phagocytosis contributes considerably to the removal of ferroptotic cells, which could release a DAMP called HMGB1 to activate and recruit macrophages, alerting immune defenses ( In the context of ferroptosis, either advanced glycosylation end-product specific receptor (AGER) or Toll-like receptors (TLR) on macrophages is required for DAMPs to mediate inflammation

Hibbs JB Jr, Taintor RR, Vavrin Z, Rachlin EM

The indoleamine structure of melatonin helps it exert antioxidant as well as anti-inflammatory effects in addition to acting on the SCN (the circadian master clock) to synchronize day-night rhythms